Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, China

BMC Pregnancy and Childbirth

Research Article

Sijuan Xu¹  Wei Dai¹  Ling Lv¹  Xiaochun He¹  Baohong Mao¹  Weitao Qiu¹  Yawen Shao¹  Hongmei Cui¹  Zhongfeng Tang¹  Min Zhou¹  Qing Liu¹  Jie Qiu¹  Xiaoying Xu¹  Xiaojuan Lin¹  Nan Zhao²  Dennis Wang²  Huang Huang²  Yawei Zhang³ 

[1] Gansu Provincial Maternity and Child Care Hospital, 143 North Road, Qilihe District, 730050, Lanzhou, Gansu Province, China;Yale University School of Public Health, 60 College Street, 06520, New Haven, CT, USA;Yale University School of Public Health, 60 College Street, 06520, New Haven, CT, USA;Yale School of Medicine, New Haven, CT, USA;

关键词: Pre-pregnancy BMI;    Gestational weight gain;    Preeclampsia;    China;    Birth cohort;   

DOI  :  10.1186/s12884-017-1567-2

 received in 2016-11-21, accepted in 2017-11-06,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo evaluate the independent and joint effects of maternal pre-pregnancy BMI and gestational weight gain (GWG) on the risk of preeclampsia and its subtypes.MethodsA birth cohort study was conducted from 2010 to 2012 in Lanzhou, China. Three hundred fourty seven pregnant women with preeclampsia and 9516 normotensive women at Gansu Provincial Maternity and Child Care Hospital were included in the present study. Unconditional logistic regression models were used to evaluate the associations between pre-pregnancy BMI, GWG, and risk of preeclampsia and its subtypes.ResultsCompared to women with normal pre-pregnancy BMI, those who were overweight/obese had an increased risk of preeclampsia (OR = 1.81; 95%CI: 1.37–2.39). Women with excessive GWG had an increased risk of preeclampsia (OR = 2.28; 95%CI: 1.70–3.05) compared to women with adequate GWG. The observed increased risk was similar for mild-, severe- and late-onset preeclampsia. No association was found for early-onset preeclampsia. Overweight/obese women with excessive GWG had the highest risk of developing preeclampsia compared to normal weight women with no excessive weight gain (OR = 3.78; 95%CI: 2.65–5.41).ConclusionsOur results suggested that pre-pregnancy BMI and GWG are independent risk factors for preeclampsia and that the risk might vary by preeclampsia subtypes. Our study also proposed a potential synergistic effect of pre-pregnancy BMI and GWG that warrants further investigation.

【 授权许可】

CC BY   
© The Author(s). 2017