Exposure to multiple metals and prevalence for preeclampsia in Taiyuan, China

Environment International

Keke Wang¹  Xiaoming Shi²  Tianbi Han³  Hailan Yang³  Xi Chen³  Bingjie Xie³  Yongliang Feng³  Pengge Guo³  Yawei Zhang³  Ping Zhang³  Joshua L. Warren³  Ying Wang³  Mei Li⁴  Weiwei Wu⁵  Suping Wang⁵ 

[1] Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA;Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA;Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, China;Department of Obstetrics, The First Affiliated Hospital, Shanxi Medical University, Taiyuan, China;National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China;

关键词: Mixture analysis;    Multi-metals;    Preeclampsia;    Pre-pregnancy BMI;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Several studies with small sample size have reported inconsistent associations between single metal and preeclampsia (PE). Very few studies have investigated metal mixtures and PE. Methods: Blood concentrations of chromium (Cr), cadmium, mercury (Hg), arsenic (As), lead (Pb), nickel, cobalt, and antimony were measured using inductively coupled plasma-mass spectrometry among 427 PE women and 427 matched controls from Taiyuan, China. Multivariate logistic regression models, weighted quantile sum (WQS) regression, and principal component analysis were employed to examine exposure to single metals and metal mixtures in relation to PE. Results: An increased prevalence of PE was associated with Cr (OR = 1.76, 95% CI: 1.18, 2.62 and 1.90, 1.22, 2.93 for the middle and high vs. low), Hg (OR = 1.60, 95% CI: 1.08, 2.38 for the high vs. low) and As (OR = 1.64, 95% CI: 1.07, 2.52 for the middle vs. low). The WQS index, predominated by Cr, Hg, Pb, and As, was positively associated with PE. A principal component characterized by Cr and As also exhibited excessive association with PE. The highest PE prevalence was found among women who were overweight/obese before pregnancy and had high Cr levels compared to women who had pre-pregnancy normal body mass index (BMI) and low Cr levels. Conclusions: Our study provided evidence that exposure to multiple metals was associated with increased prevalence of PE, and the observed association with multiple metals was dominated by Cr, As. Our study also suggested that pre-pregnancy BMI might modify the association between Cr and PE.

【 授权许可】

Unknown