Antinociceptive and anti-tussive activities of the ethanol extract of the flowers of Meconopsis punicea Maxim

BMC Complementary and Alternative Medicine

Research Article

Yu Zhang¹  Yu Wang²  Xiaofei Shang²  Dongsheng Wang²  Jiyu Zhang²  Xiaolou Miao²  Xuezhi Wang²  Hu Pan² 

[1] Department of Emergency, Lanzhou General Hospital of PLA, 730050, Lanzhou, People's Republic of China;Key Laboratory of New Animal Drug Project, Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, 730050, Lanzhou, People's Republic of China;

关键词: Meconopsis punicea;    Antinociceptive activity;    Formalin test;    Antitussive activity;   

DOI  :  10.1186/s12906-015-0671-y

 received in 2014-12-12, accepted in 2015-05-13,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAs an important traditional Tibetan (veterinary) medicine, the flowers of Meconopsis punicea (family Papaveraceae) have been used to treat pain, fever, cough, inflammation, liver heat and lung heat of humans and animals by local people for thousands of years. In this paper, we aimed to investigate the antinociceptive and anti-tussive activities of the ethanol extract of M. punicea (EEM).MethodsFirstly, HPLC was used to analyze the main constituents of the ethanol extract of M. punicea. In animal experiments, the acetic acid-induced writhing response test, hot plate test, barbiturate-induced sleeping time and formalin tests were used to evaluate the antinociceptive activity. Then, ammonia-induced coughing and sulfur dioxide-induced coughing tests in mice as well as the phenol red secretion in trachea test were used to investigate the anti-tussive activity of the extract. Finally, an acute toxicity study was carried out.ResultsThe results showed that alkaloids and flavonoids were the main compounds in the ethanol extract of M. punicea flowers. The extract at 125, 250 and 500 mg/kg had good antinociceptive and anti-tussive activities in mice with a dose-dependent manner.ConclusionsThese findings suggested that EEM has significant bioactivities, and the active components of M. punicea should be studied further.

【 授权许可】

Unknown   
© Shang et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.