Combined effects of sleep quality and depression on quality of life in patients with type 2 diabetes

BMC Family Practice

Research Article

Peian Lou¹  Guiqiu Chang²  Lei Zhang²  Cheng Qiao²  Ting Li²  Peipei Chen²  Pan Zhang³ 

[1] Department of Control and Prevention of Chronic Non-communicable Diseases, Xuzhou Center for Disease Control and Prevention, School of Public Health, Xuzhou Medical University, 42 West Erhuan Road, Xuzhou, Jiangsu, China;Department of Control and Prevention of Chronic Non-communicable Diseases, Xuzhou Center for Disease Control and Prevention, Xuzhou, China;School of Public Health, Xuzhou Medical University, Xuzhou, China;

关键词: Type 2 diabetes mellitus;    Sleep quality;    Depression;    Diabetes specificity quality of life scale;    Interaction;    Relative excess risk of interaction;    Attributable proportion;    Synergy index;   

DOI  :  10.1186/s12875-016-0435-x

 received in 2015-07-10, accepted in 2016-03-22,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPoor sleep quality and depression negatively impact the health-related quality of life of patients with type 2 diabetes, but the combined effect of the two factors is unknown. This study aimed to assess the interactive effects of poor sleep quality and depression on the quality of life in patients with type 2 diabetes.MethodsPatients with type 2 diabetes (n = 944) completed the Diabetes Specificity Quality of Life scale (DSQL) and questionnaires on sleep quality and depression. The products of poor sleep quality and depression were added to the logistic regression model to evaluate their multiplicative interactions, which were expressed as the relative excess risk of interaction (RERI), the attributable proportion (AP) of interaction, and the synergy index (S).ResultsPoor sleep quality and depressive symptoms both increased DSQL scores. The co-presence of poor sleep quality and depressive symptoms significantly reduced DSQL scores by a factor of 3.96 on biological interaction measures. The relative excess risk of interaction was 1.08. The combined effect of poor sleep quality and depressive symptoms was observed only in women.ConclusionsPatients with both depressive symptoms and poor sleep quality are at an increased risk of reduction in diabetes-related quality of life, and this risk is particularly high for women due to the interaction effect. Clinicians should screen for and treat sleep difficulties and depressive symptoms in patients with type 2 diabetes.

【 授权许可】

CC BY   
© Zhang et al. 2016