A novel systems pharmacology model for herbal medicine injection: a case using reduning injection

BMC Complementary and Alternative Medicine

Research Article

Wei Zhou¹  Yao Yao¹  Wenjuan Zhang²  Yonghua Wang²  Chao Huang²  Haixing Yang³  Zhenzhong Wang⁴  Wei Xiao⁴  Yan Li⁵ 

[1] Center of Bioinformatics, Northwest A & F University, 712100, Yangling, Shaanxi, China;Center of Bioinformatics, Northwest A & F University, 712100, Yangling, Shaanxi, China;College of Life Sciences, Northwest A & F University, 712100, Yangling, Shaanxi, China;Center of Bioinformatics, Northwest A & F University, 712100, Yangling, Shaanxi, China;College of Life Sciences, Northwest A & F University, 712100, Yangling, Shaanxi, China;College of Life Science, Northwest University, 710000, Xi’an, Shaanxi, China;Jiangsu Kanion Parmaceutical Co.LtD, 222002, Lianyungang, Jiangsu, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, 222002, Lianyungang, Jiangsu, China;Lab of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023, Dalian, Liaoning, China;

关键词: Systems pharmacology;    Reduning injection;    Polypharmacology;    Mechanism of action;   

DOI  :  10.1186/1472-6882-14-430

 received in 2013-12-19, accepted in 2014-10-09,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundCompared with the traditional oral administration form, injection administration is basically superior in terms of both biological availability and therapeutic effects. However, few researches have focused on the traditional Chinese medicinal injection due to the complicated constituents and the intricate mechanism of action.MethodsIn the present work, a novel systems pharmacology model, integrating ADME (absorption, distribution, metabolism, and excretion) filtering such as half-life evaluation, network targeting, pathway and systems analyses, is specifically developed for the identification of active compounds and the study of the mechanism of action of TCM injection, which is exemplified by Reduning injection confronting the influenza.ResultsThe ADME filter successfully identifies 35 bioactive compounds (31 molecules and 4 metabolites) from the Reduning injection. The systems analysis and experimental validation further reveal a new way of confronting influenza disease of this injection: 1) stimulating the immunomodulatory agents for immune response activation, and 2) regulating the inflammatory agents for anti-inflammation.ConclusionsThe novel systems pharmacology method used in this study has the potential to advance the understanding of the molecular mechanisms of action of multicomponent herbal injections, and provide clues to discovering more effective drugs against complex diseases.

【 授权许可】

Unknown   
© Yang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.