Increased default mode network connectivity and increased regional homogeneity in migraineurs without aura

The Journal of Headache and Pain

Research Article

Yi-Lan Wu¹  Jian-Ren Liu¹  Yan-Hui Shi¹  Ge-Fei Li¹  Jingjing Su¹  Feng-Di Liu¹  Qian Yao¹  Ying Zhao¹  Qiting Zhang¹  Shuo Wang¹  Mengxing Wang²  Jilei Zhang²  Hui Zhang²  Haifeng Lu²  Jianqi Li²  Xiaoxia Du² 

[1] Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; and Clinical Research Center, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, 200011, Shanghai, People’s Republic of China;Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, 3663 North Zhong-Shan Road, 200062, Shanghai, People’s Republic of China;

关键词: Migraine;    Precuneus;    Functional connectivity;    Regional homogeneity;   

DOI  :  10.1186/s10194-016-0692-z

 received in 2016-07-27, accepted in 2016-10-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations in resting-state brain functional connectivity in the default mode network and in local regional spontaneous neuronal activity is not adequate.MethodsThis study used functional magnetic resonance imaging to acquire resting-state scans in 22 migraineurs without aura and in 22 healthy matched controls. Independent component analysis, a data-driven method, was used to calculate the resting-state functional connectivity of the default mode network in the patient and healthy control groups. Regional homogeneity (ReHo) was used to analyse the local features of spontaneous resting-state brain activity in the migraineurs without aura.ResultsCompared with the healthy controls, migraineurs without aura showed increased functional connectivity in the left precuneus/posterior cingulate cortex within the default mode network and significant increase in ReHo values in the bilateral precuneus/posterior cingulate cortex, left pons and trigeminal nerve entry zone. In addition, functional connectivity was decreased between the areas with abnormal ReHo (using the peaks in the precuneus/posterior cingulate cortex) and other brain areas.ConclusionsThe abnormalities in the precuneus/posterior cingulate cortex suggest that migraineurs without aura may exhibit information transfer and multimodal integration dysfunction and that pain sensitivity and pian processing may also be affected.

【 授权许可】

CC BY   
© The Author(s). 2016