Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder

BMC Psychiatry

Research Article

Yunxiang Tang¹  Zheng Lu²  Xingguang Luo³  Tianhong Zhang⁴  Yongguang He⁴  Yingying Tang⁴  Hui Li⁴  Jijun Wang⁵  Chunbo Li⁵  Yikang Zhu⁶ 

[1] Department of Medical Psychology, Faculty of Psychology and Mental Health, Second Military Medical University, Shanghai, People’s Republic of China;Department of Psychiatry, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xin Cun Road, 200065, Shanghai, People’s Republic of China;Department of Psychiatry, Yale University School of Medicine, 06516, New Haven, CT, USA;Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, South Wan Ping Road 600, 200030, Shanghai, People’s Republic of China;Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, South Wan Ping Road 600, 200030, Shanghai, People’s Republic of China;Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, South Wan Ping Road 600, 200030, Shanghai, People’s Republic of China;Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar, TU München, Munich, Germany;

关键词: Schizotypal personality disorder;    Functional connectivity;    Resting state;    Precuneus;    Parahippocampus;   

DOI  :  10.1186/s12888-016-1146-5

 received in 2016-05-31, accepted in 2016-11-29,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSchizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patients with schizophrenia could be extended to individuals with SPD.MethodsTwenty subjects with SPD and 19 healthy controls were recruited from 4461 freshmen at a university in Shanghai and received a resting-state scan of MRI. All participants were evaluated by the Chinese version of Schizotypal Personality Questionnaire (SPQ) and the Chinese version of Symptom Checklist (SCL-90). The imaging data were analysed using the seed-based functional connectivity method.ResultsCompared with the controls, SPD subjects exhibited reduced FC between bilateral precuneus and contralateral parahippocampus. In SPD group, SPQ total score was negatively correlated with FC between right precuneus and left parahippocampus (r = −0.603, p = 0.006); there was a negative trend between SPQ subscale score of suspiciousness and FC between left precuneus and right parahippocampus (r = −0.553, p = 0.014); and a positive trend was found between SPQ subscale score of odd or eccentric behaviour and FC between left precuneus and right superior temporal gyrus (r = 0.543, p = 0.016). As for the SCL-90 score, a similar negative trend was found between SCL-90 subscale score of suspiciousness and FC between right precuneus and left parahippocampus (r = −0.535, p = 0.018) in SPD group.ConclusionsOur findings suggest that the decreased functional connectivity between precuneus and contralateral parahippocampus might play a key role in the pathophysiology of schizophrenia spectrum disorder.

【 授权许可】

CC BY   
© The Author(s). 2017