Omega-3 fatty acid ameliorates bisphenol F-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling

Frontiers in Endocrinology

Endocrinology

Wale Johnson Adeyemi¹  Luqman Aribidesi Olayaki²  Adeyemi Fatai Odetayo³ 

[1] Physiology Department, Adeleke University, Ede, Nigeria;Physiology Department, University of Ilorin, Ilorin, Nigeria;Physiology Department, University of Ilorin, Ilorin, Nigeria;Physiology Department, Federal University of Health Sciences, Ila Orangun, Osun State, Nigeria;

关键词: omega-3 fatty acid;    bisphenol F;    bisphenol analogs;    endocrine disruptors;    testicular functions;    apoptosis;   

DOI  :  10.3389/fendo.2023.1256154

 received in 2023-07-10, accepted in 2023-09-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionBisphenol F (BPF) has been shown to disrupt testicular functions via perturbation of testicular redox balance, while omega-3 fatty acid (O3FA) has been established to exert antioxidant and anti-inflammatory activities. Therefore, this study focused on the role and associated molecular mechanism of O3FA in BPF-induced testicular dysfunction in male Wistar rats.MethodsTwenty-four (24) rats were randomly grouped after two weeks of acclimatization into four (4) groups (n=6/group); the vehicle-treated control group, BPF treated group received 30 mg/kg of BPF, and the intervention groups received 30 mg/kg BPF + 100 mg/kg O3FA (BPF+O3FA-L) and 30 mg/kg BPF + 300 mg/kg of O3FA (BPF+O3FA-H). All treatment lasted for 28 days.ResultsLow and high doses of O3FA ameliorated BPF-impaired sperm quality, and induced hormonal imbalance, accompanied by a distortion in testicular histology and elevated testicular injury markers. Furthermore, co-administration of BPF with both doses of O3FA blunted BPF-induced redox imbalance, inflammatory response, and apoptosis.DiscussionsIn conclusion, our present findings show that O3FA improves testicular functions in BPF-treated rats by improving sperm quality and reproductive hormones via the maintenance of testicular redox balance.

【 授权许可】

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Copyright © 2023 Odetayo, Adeyemi and Olayaki