Adverse effects of maternal exposure to bisphenol F on the anxiety- anddepression-like behavior of offspring

The Journal of Veterinary Medical Science

Kentaro TANEMURA¹  Naoko OHTANI²  Erika TSUJI²  Hiroki INOUE²  Koshi SUDA²  Hiroshi YOKOTA²  Hidetomo IWANO² 

[1] Laboratory of Animal Reproduction and Development,Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555,Japan;Laboratory of Veterinary Biochemistry, Department ofBioscience, School of Veterinary Medicine, Rakuno Gakuen University, 582Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan

关键词: anxiety behavior;    bisphenol A;    bisphenol F;    depression;    endocrine disruptors;   

DOI  :  10.1292/jvms.16-0502

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Bisphenol A (BPA), a well-known endocrine disruptor, is metabolized and eliminatedrapidly from the body in adult animals. However, many authors have reported that perinatalBPA exposure alters development of the brain, reproductive system and behavior in the nextgeneration. Recently, BPA substitutes, especially bisphenol F (BPF), have been usedbecause of concerns about the influence of BPA on children, although the actual effects onthe next generation are unknown. In this study, we observed behavioral adverse effects ofthe offspring of mice exposed to BPA or BPF in fetal period. Female C57BL/6 mice weregiven oral BPA or BPF (0 or 10 mg/kg body weight) daily from gestational day 11.5 to 18.5.The open field test, the elevated plus maze test and the forced swim test were performedat postnatal week 10. BPF exposure altered offspring behavior significantly, resulting inincreases in anxiety and depressive state. The influence of BPF was stronger than that ofBPA. We demonstrated novel evidence that BPF influences the behavior of offspring.

【 授权许可】

Unknown