Endometrial scratching during hysteroscopy in women undergoing in vitro fertilization: a systematic review and meta-analysis

Frontiers in Surgery

Surgery

Grigorios Grimpizis¹  Antonios Skalias²  Ioannis Tsakiridis³  Apostolos Mamopoulos³  Apostolos Athanasiadis³  Georgios Michos³  Robert Najdecki⁴  Evangelos Papanikolaou⁴  Nikolaos Peitsidis⁵  Dimitrios Patoulias⁶  Alexandros Poutoglidis⁷ 

[1] 1st Department of Obstetrics and Gynaecology, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;2nd Academic Otorhinolaryngology, Head and Neck Surgery Department, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;3rd Department of Obstetrics and Gynaecology, General Hospital Hippocrateion, Aristotle University of Thessaloniki, Thessaloniki, Greece;Assisting Nature IVF Centre and Genetics, Thessaloniki, Greece;Assisting Nature IVF Centre and Genetics, Thessaloniki, Greece;3rd Department of Obstetrics and Gynaecology, General Hospital Hippocrateion, Aristotle University of Thessaloniki, Thessaloniki, Greece;Department of Obstetrics and Gynaecology, Interbalkan Hospital, Thessaloniki, Greece;Department of Otorhinolaryngology, Head and Neck Surgery, “G. Papanikolaou” General Hospital, Thessaloniki, Greece;

关键词: hysteroscopy;    endometrial scratching;    IVF;    repeated implantation failure;    reproductive outcomes;   

DOI  :  10.3389/fsurg.2023.1225111

 received in 2023-05-18, accepted in 2023-09-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveEndometrial scratching (ES) during hysteroscopy before embryotransfer (ET) remains doubtable on whether it benefits the reproductive outcomes. The optimal technique is not clear and repeated implantation failure as a challenging field in in vitro fertilization (IVF) seems to be the springboard for clinicians to test its effectiveness.MethodsMedline, PMC, ScienceDirect, Scopus, CENTRAL, Google Scholar were searched from their inception up to April 2023 for studies to evaluate the effectiveness of adding endometrial scratching during hysteroscopy before ET.ResultsThe initial search yielded 959 references, while 12 eligible studies were included in the analyses, involving 2,213 patients. We found that hysteroscopy and concurrent ES before ET resulted in a statistically significant improvement in clinical pregnancy rate (CPR) [RR = 1.50, (95% CI 1.30–1.74), p < 0.0001] and live birth rate (LBR) [RR = 1.67, (95% CI 1.30–2.15), p < 0.0001] with no statistically significant difference on miscarriage rate [RR = 0.80 (95% CI 0.52–1.22), p = 0.30]ConclusionOur meta-analysis suggests that hysteroscopy with concurrent ES may be offered in IVF before ET as a potentially improving manipulation. Future randomized trials comparing different patient groups would also provide more precise data on that issue, to clarify specific criteria in the selection of patients.Systematic Review RegistrationPROSPERO (CRD42023414117)

【 授权许可】

Unknown   
© 2023 Papanikolaou, Peitsidis, Tsakiridis, Michos, Skalias, Patoulias, Poutoglidis, Mamopoulos, Athanasiadis, Grimpizis and Najdecki.