Site-specific endometrial injury improves implantation and pregnancy in patients with repeated implantation failures

Reproductive Biology and Endocrinology

Chia Lin Chang¹  Chieh Yu Lin¹  Mei Li Wang¹  Hsin-Shih Wang¹  Yung-Kuei Soong¹  Chin-Jung Wang¹  Shang Yu Huang¹ 

[1] Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, 5 Fu-Shin Street, Kweishan, Taoyuan, Taiwan

关键词: pregnancy;    repeated implantation failure;    IVF;    endometrium biopsy;    hysteroscopy;   

Others  :  1151413
DOI  :  10.1186/1477-7827-9-140

 received in 2011-06-03, accepted in 2011-10-21,  发布年份 2011

【 摘 要 】

Background

To test whether a site-specific hysteroscopic biopsy-induced injury in the endometrium during the controlled ovarian hyperstimulation cycle improves subsequent embryo implantation in patients with repeated implantation failure, a total of 30 patients who have had good responses to controlled ovulation stimulation but have failed to achieve pregnancy after two or more transfers of good-quality embryos were recruited in this prospective study.

Methods

A single, site-specific hysteroscopic biopsy-induced injury was generated on the posterior endometrium at midline 10-15 mm from the fundus during the D4-D7 period of the ongoing controlled ovarian hyperstimulation cycle in six patients.

Results

Patients received endometrial biopsy protocol achieved a pregnancy rate of 100%. By contrast, only 46% of patients with similar clinical characteristics (N = 24) achieved pregnancy without the hysteroscopic biopsy-induced endometrium injury (p < 0.05).

Conclusions

Our proof-of-concept study demonstrates that a site-specific hysteroscopic endometrium injury performed during the ongoing in vitro fertilization (IVF) cycle, instead of injuries received during prior cycles, significantly improves clinical outcomes in patients with repeated implantation failure.

【 授权许可】

   
2011 Huang et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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