Reproductive Biology and Endocrinology | |
Site-specific endometrial injury improves implantation and pregnancy in patients with repeated implantation failures | |
关键词: hysteroscopy; endometrium biopsy; IVF; repeated implantation failure; pregnancy; | |
DOI : 10.1186/1477-7827-9-140 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
To test whether a site-specific hysteroscopic biopsy-induced injury in the endometrium during the controlled ovarian hyperstimulation cycle improves subsequent embryo implantation in patients with repeated implantation failure, a total of 30 patients who have had good responses to controlled ovulation stimulation but have failed to achieve pregnancy after two or more transfers of good-quality embryos were recruited in this prospective study.
Methods
A single, site-specific hysteroscopic biopsy-induced injury was generated on the posterior endometrium at midline 10-15 mm from the fundus during the D4-D7 period of the ongoing controlled ovarian hyperstimulation cycle in six patients.
Results
Patients received endometrial biopsy protocol achieved a pregnancy rate of 100%. By contrast, only 46% of patients with similar clinical characteristics (
Conclusions
Our proof-of-concept study demonstrates that a site-specific hysteroscopic endometrium injury performed during the ongoing
【 授权许可】
Unknown