Innate immune response restarts adaptive immune response in tumors

Frontiers in Immunology

Immunology

Qing-qing Zhang¹  Guo-qiang Yuan²  Qiao Li²  Shang-yu Liu²  Ya-wen Pan²  Wen-shan Li³ 

[1] Department of Respiratory and Critical Care Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai, China;The Department of Neurosurgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu, China;Key Laboratory of Neurology of Gansu Province, The Second Hospital of Lanzhou University, Lanzhou, Gansu, China;The Department of Neurosurgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu, China;Key Laboratory of Neurology of Gansu Province, The Second Hospital of Lanzhou University, Lanzhou, Gansu, China;Department of Neurosurgery, Qinghai Provincial People’s Hospital, Xining, Qinghai, China;

关键词: DNA sensing;    RNA sensing;    crosstalk;    glioblastoma;    type I interferon;   

DOI  :  10.3389/fimmu.2023.1260705

 received in 2023-07-20, accepted in 2023-08-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

The imbalance of immune response plays a crucial role in the development of diseases, including glioblastoma. It is essential to comprehend how the innate immune system detects tumors and pathogens. Endosomal and cytoplasmic sensors can identify diverse cancer cell antigens, triggering the production of type I interferon and pro-inflammatory cytokines. This, in turn, stimulates interferon stimulating genes, enhancing the presentation of cancer antigens, and promoting T cell recognition and destruction of cancer cells. While RNA and DNA sensing of tumors and pathogens typically involve different receptors and adapters, their interaction can activate adaptive immune response mechanisms. This review highlights the similarity in RNA and DNA sensing mechanisms in the innate immunity of both tumors and pathogens. The aim is to enhance the anti-tumor innate immune response, identify regions of the tumor that are not responsive to treatment, and explore new targets to improve the response to conventional tumor therapy and immunotherapy.

【 授权许可】

Unknown   
Copyright © 2023 Li, Zhang, Li, Liu, Yuan and Pan