Graphene supported hafnium oxide nanopores for DNA sensing

nanopores;DNA sensing;graphene;solid-state nanopores;graphene membrane;transmission electron microscopy (TEM)

Rivera, Jose ; Bashir ; Rashid

关键词: nanopores;    DNA sensing;    graphene;    solid-state nanopores;    graphene membrane;    transmission electron microscopy (TEM);   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/44455/Jose_Rivera.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

The completion of the Human Genome Project in 2001 has served as both an inspiration and a challenge for researchers in the past decade. Understanding the genetic makeup of organisms is crucial for early disease detection, one of the driving forces behind personalized medicine. In this work, state-of-the-art sequencing technologies are reviewed and compared with next-generation sequencing technologies. In particular, solid-state nanopores are investigated and recent developments in the field are discussed. The interdisciplinary effort from researchers to establish solid-state nanopores as a viable sequencing platform is thriving on multiple fronts including surface charge engineering for DNA capture and conductance modulation in nanopores, nanowire transistors for localized detection, ultra-thin membrane fabrication using graphene, and the exploration of alternative nanopore materials for biosensing applications. In this work, the development of a new solid-state nanopore sensor consisting of hafnium oxide suspended by functionalized graphene is reported along with DNA transport properties and dielectric characterization of the film in solution.