Contribution of viral and bacterial infections to senescence and immunosenescence

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Antonia Reyes¹  Linmar Rodriguez-Guilarte¹  Pablo A. González¹  Catalina A. Andrade¹  Gerardo Ortiz¹  Alexis M. Kalergis²  Luisa F. Duarte³  Felipe Simon⁴  Claudia A. Riedel⁴  Yolanda Prado⁴  Rosario Hernández-Armengol⁴  Christian Fernández⁵  Mónica Cáceres⁵  Leandro J. Carreño⁶  Pablo A. Palacios⁶ 

[1] Millennium Institute on Immunology and Immunotherapy, Santiago, Chile;Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile;Millennium Institute on Immunology and Immunotherapy, Santiago, Chile;Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile;Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile;Millennium Institute on Immunology and Immunotherapy, Santiago, Chile;Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile;Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile;Millennium Institute on Immunology and Immunotherapy, Santiago, Chile;Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile;Millennium Institute on Immunology and Immunotherapy, Santiago, Chile;Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, Chile;Millennium Institute on Immunology and Immunotherapy, Santiago, Chile;Programa de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile;

关键词: senescence;    immunosenescence;    chronic infections;    persistent infections;    virus;    bacteria;    SASP;   

DOI  :  10.3389/fcimb.2023.1229098

 received in 2023-05-25, accepted in 2023-08-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cellular senescence is a key biological process characterized by irreversible cell cycle arrest. The accumulation of senescent cells creates a pro-inflammatory environment that can negatively affect tissue functions and may promote the development of aging-related diseases. Typical biomarkers related to senescence include senescence-associated β-galactosidase activity, histone H2A.X phosphorylation at serine139 (γH2A.X), and senescence-associated heterochromatin foci (SAHF) with heterochromatin protein 1γ (HP-1γ protein) Moreover, immune cells undergoing senescence, which is known as immunosenescence, can affect innate and adaptative immune functions and may elicit detrimental effects over the host’s susceptibility to infectious diseases. Although associations between senescence and pathogens have been reported, clear links between both, and the related molecular mechanisms involved remain to be determined. Furthermore, it remains to be determined whether infections effectively induce senescence, the impact of senescence and immunosenescence over infections, or if both events coincidently share common molecular markers, such as γH2A.X and p53. Here, we review and discuss the most recent reports that describe cellular hallmarks and biomarkers related to senescence in immune and non-immune cells in the context of infections, seeking to better understand their relationships. Related literature was searched in Pubmed and Google Scholar databases with search terms related to the sections and subsections of this review.

【 授权许可】

Unknown   
Copyright © 2023 Reyes, Ortiz, Duarte, Fernández, Hernández-Armengol, Palacios, Prado, Andrade, Rodriguez-Guilarte, Kalergis, Simon, Carreño, Riedel, Cáceres and González