γ/δ T cell subsets in human aging using the classical α/β T cell model

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: immunosenescence;    cell differentiation;    penotyping;    persistent infections;    CD4/CD8 ratio;    cellular markers;   

DOI  :  10.1189/jlb.5A1213-650RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Agingisassociatedwithanincreasedsusceptibilitytoinfectionsanddiseases.Ithasalsobeenassociatedwithreducedfunctionalityandaltereddistributionofimmunecells,especiallyTcells.Whereasclassicalα/βTcells,especiallyCD8+Tcells,wereshowntobehighlysusceptibletoaging,theeffectsofviralpersistentstimulationsonthefateofγ/δTcellsaremuchlessdocumented.Healthy,elderlyindividualsofChineseethnicalbackgroundwererecruitedundertheaegisofSLAS‐II.Inthisobservationalstudy,γ/δTcellpopulationswerecharacterizedbyflowcytometryandcomparedwiththeα/βCD4+andCD8+Tcellsinelderlyandyoungcontrols.Inourstudy,weidentifiedareducedfrequencyofγ/δTcellsbutnotα/βTcellswithaging.Theclassicalmarkersofα/βTcellaging,includingCD28,CD27,andCD57,didnotprovesignificantforγ/δTcells.Theextremerangeofexpressionofthesemarkersinγ/δTcellswasresponsibleforthelackofrelationshipbetweenγ/δTcellsubsets,CD4/CD8ratio,andanti‐CMVtitersthatwassignificantforα/βTcellsand,especially,CD8+Tcells.Althoughmarkersofagingforγ/δTcellsarenotclearlyidentified,ourdatacollectivelysuggestthatthepresenceofCD27γ/δTcellsisassociatedwithmarkersofα/βTcellaging...

【 授权许可】

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