Low Dose IR Creates an Oncogenic Microenvironment by Inducing Premature

Yuan, Zhi-Min¹ 

[1] Harvard School of Public Health

关键词: Low doses radiation;    senescence;    microenvironment;   

DOI  :  10.2172/1076860
RP-ID  :  Final Report
PID  :  OSTI ID: 1076860
Others  :  Other: 275-23495-111384

学科分类：生物科学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

Introduction Much of the work addressing ionizing radiation-induced cellular response has been carried out mainly with the traditional cell culture technique involving only one cell type, how cellular response to IR is influenced by the tissue microenvironment remains elusive. By use of a three-dimensional (3D) co-culture system to model critical interactions of different cell types with their neighbors and with their environment, we recently showed that low-dose IR-induced extracellular signaling via the tissue environment affects profoundly cellular responses. This proposal aims at determining the response of mammary epithelial cells in a tissue-like setting.