WNT16B from Ovarian Fibroblasts Induces Differentiation of Regulatory T Cells through β-Catenin Signal in Dendritic Cells

International Journal of Molecular Sciences

Cong-Cong Shen³  Yu-Huan Kang³  Ming Zhao¹  Yi He³  Dan-Dan Cui²  Yu-Yin Fu³  Ling-Lin Yang¹ 

[1] Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China; E-Mail:;Department of Medical Oncology, the Fifth People’s Hospital of Chengdu, Chengdu 611130, China; E-Mail:;State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China; E-Mails:

关键词: WNT16B;    fibroblasts;    regulatory T cells;    dendritic cells;    microenvironment;   

DOI  :  10.3390/ijms150712928

来源: mdpi

【 摘 要 】

Treatment for cancer can induce a series of secreted factors into the tumor microenvironment, which can affect cancer progression. Wingless-type MMTV (mouse mammary tumor virus) integration site 16B (WNT16B) is a new member of the WNT family and has been reported to play growth-related roles in previous studies. In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation. We also demonstrated that fibroblast-derived WNT16B could result in accumulation of β-catenin in dendritic cells and secretion of interleukin-10 (IL-10) and transforming growth factor beta (TGF-β), which contributed to the differentiation of regulatory T cells in a co-culture environment. These results shed light on the roles of WNT16B in immune regulation, especially in regard to cancer treatment.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.