Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms

Frontiers in Physiology

Physiology

Aijiao Yu¹  Zhiwen Zhang¹  Qi Wang²  Youfan Zhang²  Jianglin Zhang³  Zhenjun Deng³  Yixiu Zhong³  Kaifen Xiong⁴ 

[1] Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China;Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China;Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China;Department of Dermatology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China;Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China;

关键词: exosomes;    conditioned medium;    mesenchymal stem cell;    keloid;    hypertrophic scar;   

DOI  :  10.3389/fphys.2023.1247734

 received in 2023-06-26, accepted in 2023-08-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

Exosomes, ranging from 40 to 160 nm in diameter, are extracellular lipid bilayer microvesicles that regulate the body’s physiological and pathological processes and are secreted by cells that contain proteins, nucleic acids, amino acids and other metabolites. Previous studies suggested that mesenchymal stem cell (MSC)-derived exosomes could either suppress or support keloid and hypertrophic scar progression. Although previous research has identified the potential value of MSC-exosomes in keloid and hypertrophic scar, a comprehensive analysis of different sources of MSC-exosome in keloid and hypertrophic scar is still lacking. This review mainly discusses different insights regarding the roles of MSC-exosomes in keloid and hypertrophic scar treatment and summarizes possible underlying mechanisms.

【 授权许可】

Unknown   
Copyright © 2023 Zhong, Zhang, Yu, Zhang, Deng, Xiong, Wang and Zhang.