Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities

International Journal of Molecular Sciences

Jose Schneider¹  Patricia Diaz-Rodriguez²  Mariana Landin²  Roman Perez-Fernandez³  Francisco J. Vizoso⁴  Paloma Esparza⁴  Noemi Eiro⁴  Luis Costa⁴ 

[1] Department of Obstetrics and Gynecology, Universidad Rey Juan Carlos, Avda. de Atenas s/n, 28922 Alcorcón, Spain;Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela-Campus Vida, 15782 Santiago de Compostela, Spain;Department of Physiology-Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, 15706 Santiago de Compostela, Spain;Research Unit, Fundación Hospital de Jove, Avda. Eduardo Castro, 161, 33290 Gijón, Spain;

关键词: Regenerative medicine;    aging diseases;    diabetes;    lupus;    secretome;    conditioned medium;    extracellular vesicles;    exosomes;   

DOI  :  10.3390/ijms20153738

来源: DOAJ

【 摘 要 】

Mesenchymal stem cells (MSCs) are present in all organs and tissues, playing a well-known function in tissue regeneration. However, there is also evidence indicating a broader role of MSCs in tissue homeostasis. In vivo studies have shown MSC paracrine mechanisms displaying proliferative, immunoregulatory, anti-oxidative, or angiogenic activity. In addition, recent studies also demonstrate that depletion and/or dysfunction of MSCs are associated with several systemic diseases, such as lupus, diabetes, psoriasis, and rheumatoid arthritis, as well as with aging and frailty syndrome. In this review, we hypothesize about the role of MSCs as keepers of tissue homeostasis as well as modulators in a variety of inflammatory and degenerative systemic diseases. This scenario opens the possibility for the use of secretome-derived products from MSCs as new therapeutic agents in order to restore tissue homeostasis, instead of the classical paradigm “one disease, one drug”.

【 授权许可】

Unknown