Type 1 invariant natural killer T cells in chronic inflammation and tissue fibrosis

Frontiers in Immunology

Immunology

Albert Agro¹  Marc Hertz¹  Vipin Kumar²  Adam J. Byrne³ 

[1] GRI Bio, La Jolla, CA, United States;Laboratory of Immune Regulation, Department of Medicine, University of California San Diego, La Jolla, CA, United States;GRI Bio, La Jolla, CA, United States;National Heart and Lung Institute, Imperial College London, London, United Kingdom;School of Medicine and Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland;

关键词: CD1d;    NKT cells;    fibrosis;    macrophages;    fibroblasts;    IPF;    NASH;   

DOI  :  10.3389/fimmu.2023.1260503

 received in 2023-07-17, accepted in 2023-09-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Chronic tissue inflammation often results in fibrosis characterized by the accumulation of extracellular matrix components remodeling normal tissue architecture and function. Recent studies have suggested common immune mechanisms despite the complexity of the interactions between tissue-specific fibroblasts, macrophages, and distinct immune cell populations that mediate fibrosis in various tissues. Natural killer T (NKT) cells recognizing lipid antigens bound to CD1d molecules have been shown to play an important role in chronic inflammation and fibrosis. Here we review recent data in both experimental models and in humans that suggest a key role of type 1 invariant NKT (iNKT) cell activation in the progression of inflammatory cascades leading to recruitment of neutrophils and activation of the inflammasome, macrophages, fibroblasts, and, ultimately, fibrosis. Emerging evidence suggests that iNKT-associated mechanisms contribute to type 1, type 2 and type 3 immune pathways mediating tissue fibrosis, including idiopathic pulmonary fibrosis (IPF). Thus, targeting a pathway upstream of these immune mechanisms, such as the inhibition of iNKT activation, may be important in modulating various fibrotic conditions.

【 授权许可】

Unknown   
Copyright © 2023 Kumar, Hertz, Agro and Byrne