期刊论文详细信息
Molecules | |
Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer | |
Meena S. Thakur1  Amy R. Howell1  Mitchell Kronenberg2  Archana Khurana2  | |
[1] Department of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USA;La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA; | |
关键词: β-GalCer; antigens; NKT cells; CD1d; | |
DOI : 10.3390/molecules190710090 | |
来源: DOAJ |
【 摘 要 】
Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown2ꞌꞌ-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.
【 授权许可】
Unknown