Synthesis of a 2''-Deoxy-β-GalCer

Molecules

Meena S. Thakur¹  Archana Khurana²  Mitchell Kronenberg² 

[1] Department of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USA;La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA

关键词: β-GalCer;    antigens;    NKT cells;    CD1d;   

DOI  :  10.3390/molecules190710090

来源: mdpi

【 摘 要 】

Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2''-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.