Healing effects of autologous platelet gel and growth factors on cutaneous leishmaniasis wounds in addition to antimony; a self-controlled clinical trial with randomized lesion assignment

BMC Research Notes

Research Note

Akbar Hashemi Tayer¹  Ahmad Meshkin²  Fatemeh Sadeghi³  Kavous Solhjoo⁴  Enayatollah Shadmand⁴  Ali Taghipour⁴ 

[1] Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran;School of Medicine, Gerash University of Medical Sciences, Gerash, Iran;School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran;Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran;Department of Medical Parasitology and Mycology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran;

关键词: Platelets gel;    Cutaneous leishmaniasis;    Growth factors;    Wound healing;   

DOI  :  10.1186/s13104-023-06470-4

 received in 2023-02-12, accepted in 2023-08-22,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveAutologous platelet gel (APG) is used in most surgeries to treat a variety of tissue defects because of its healing factors composition. This randomized parallel clinical trial was conducted to investigate the healing effects of APG on cutaneous leishmaniasis (CL) wounds. Eighteen male patients with CL wounds were recruited and followed for two months. The patients had more than one cutaneous wound, one of which was examined as the control and the other one as the intervention wound. APG was applied to the intervention wounds once a week, up to eight times. The primary endpoint was wound healing which defined as complete epithelialization and tissue granulation. Other clinical evaluation criteria were assessment of the wound size, and histopathology analyses.ResultsOf 18 patients, 15 patients completed the trial (83.3%, mean age 28 years). The use of APG on the wounds was associated with complete and faster healing in 66% of the wounds and partial healing in 34% of the wounds. During the study, none of the control wounds were completely healed. The wound area in the intervention cases showed a statistically significant decrease throughout the study (P < 0.01) compared with controls. Following treatment of CL lesions with APG, the inflammatory process in the epidermis and dermis were decreased significantly (P < 0.01) compared with controls.ConclusionOur preliminary results confirm the clinical healing improvement described in the literature for APG-GF treatment of chronic non-leishmania wounds via immunomodulation.Trial registration: IRCT, IRCT20190212042694N1. Registered 20 February 2019, https://en.irct.ir/trial/37522

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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