Functional roles of magnetic nanoparticles for the identification of metastatic lymph nodes in cancer patients

Journal of Nanobiotechnology

Review

Wei Liu¹  Zhijie Xu¹  Yuanliang Yan²  Yuanhong Liu²  Qiuju Liang²  Yuzhen Xu³  Tongfei Li⁴  Kui Zhang⁵  Abhimanyu Thakur⁵ 

[1] Department of Pathology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Pharmacy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Rehabilitation, The Second Affiliated Hospital of Shandong First Medical University, 271000, Taian, Shandong, China;Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, 442000, Shiyan, Hubei, China;Pritzker School of Molecular Engineering, Ben May Department for Cancer Research, University of Chicago, 60637, Chicago, IL, USA;

关键词: Magnetic nanoparticles;    Metastatic lymph nodes;    Iron oxide;    Bioimaging;    Cancer diagnosis and treatment;   

DOI  :  10.1186/s12951-023-02100-0

 received in 2023-05-23, accepted in 2023-09-08,  发布年份 2023

来源: Springer

【 摘 要 】

Staging lymph nodes (LN) is crucial in diagnosing and treating cancer metastasis. Biotechnologies for the specific localization of metastatic lymph nodes (MLNs) have attracted significant attention to efficiently define tumor metastases. Bioimaging modalities, particularly magnetic nanoparticles (MNPs) such as iron oxide nanoparticles, have emerged as promising tools in cancer bioimaging, with great potential for use in the preoperative and intraoperative tracking of MLNs. As radiation-free magnetic resonance imaging (MRI) probes, MNPs can serve as alternative MRI contrast agents, offering improved accuracy and biological safety for nodal staging in cancer patients. Although MNPs’ application is still in its initial stages, exploring their underlying mechanisms can enhance the sensitivity and multifunctionality of lymph node mapping. This review focuses on the feasibility and current application status of MNPs for imaging metastatic nodules in preclinical and clinical development. Furthermore, exploring novel and promising MNP-based strategies with controllable characteristics could lead to a more precise treatment of metastatic cancer patients.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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