Burden and predictors of diabetic kidney disease in an adult Ugandan population with new-onset diabetes

BMC Research Notes

Research Note

William Lumu¹  Isaac Sekitoleko²  Davis Kibirige³ 

[1] Department of Medicine, Mengo Hospital, Kampala, Uganda;Non-Communicable Diseases Program, Medical Research Council, Research Unit, Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda, Entebbe, Uganda;Non-Communicable Diseases Program, Medical Research Council, Research Unit, Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda, Entebbe, Uganda;Department of Medicine, Uganda Martyrs Hospital Lubaga, Kampala, Uganda;

关键词: Diabetic kidney disease;    Adult patients;    New-onset diabetes;    Uganda;    Sub-saharan Africa;   

DOI  :  10.1186/s13104-023-06500-1

 received in 2022-09-06, accepted in 2023-09-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundDespite the growing evidence of diabetic kidney disease (DKD) in adult patients with long-standing diabetes in sub-Saharan Africa, data on its burden and correlates in adult African patients with new-onset diabetes are limited. We, therefore, undertook this study to determine the burden and predictors of DKD in an adult population with new-onset diabetes in Uganda.MethodsWe collected data on the relevant sociodemographic, clinical, anthropometric, and metabolic characteristics in 519 participants with newly diagnosed diabetes recruited from seven tertiary hospitals. A spot mid-stream urine sample was collected for determination of the urine albumin creatinine ratio (UACR) using Clinitek® microalbumin strips and a point-of-care Clinitek® status analyser. The estimated glomerular filtration rate (e-GFR) was determined using the Chronic Kidney Disease Epidemiology formula. The presence of DKD was defined as a spot UACR ≥ 3 mg/mmol with or without an e-GFR < 60 ml/min/1.73m2.ResultsThe median (IQR) age, UACR, and e-GFR of the participants were 48 years (39–57), 2.27 mg/mmol (1.14–3.41), and 121.8 ml/min/1.73m2 (105.4-133.9). UACR ≥ 3 mg/mmol and e-GFR < 60 ml/min/1.73m2 was noted in 175 (33.7%) and 7 (1.4%) participants, respectively. DKD was documented in 175 participants (33.7%). Compared with those without DKD, participants with DKD were more likely to be ≥ 50 years of age (53.7% vs. 43%, p = 0.02) and to have co-existing hypertension at the time of diagnosis (40.6% vs. 30.1%, p = 0.02). On multivariate analysis, self-reported hypertension comorbidity (OR 1.76 95% CI 1.24–2.48, p = 0.002) and body mass index (BMI) ≥ 30 kg/m2 (OR 0.61 95% CI 0.41–0.91, p = 0.02) were noted to independently predict DKD.ConclusionIn this study population, DKD was relatively common and was independently associated with self-reported hypertension comorbidity and BMI ≥ 30 kg/m2.

【 授权许可】

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© BioMed Central Ltd., part of Springer Nature 2023