Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder

BMC Psychiatry

Research

Do-Won Kim¹  Jin Woo Chang²  Bong Soo Kim²  Young Jun Boo³  Se Joo Kim⁴  Jee In Kang⁴  Jin Young Park⁵ 

[1] Department of Biomedical Engineering, College of Engineering Sciences, Chonnam National University, 50 Daehak-ro, Yeosu, Republic of Korea;School of Healthcare and Biomedical Engineering, College of Engineering Sciences, Chonnam National University, 50 Daehak-ro, Yeosu, Republic of Korea;Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Psychiatry, Graduate School, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea;Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea;Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea;

关键词: Obsessive-compulsive disorder;    Working memory;    Removal of information;    Delayed matching-to-sample task;    Beta oscillations;    Magnetoencephalography;   

DOI  :  10.1186/s12888-023-05149-1

 received in 2023-01-01, accepted in 2023-08-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundObsessive-compulsive disorder (OCD) is related to working memory impairment. Since patients with OCD have difficulty controlling their obsessive thoughts, removal of irrelevant information might be important in the pathophysiology of OCD. However, little is known about brain activity during the removal of information from working memory in patients with OCD. Our goal was to explore potential deficits in inhibitory function related to working memory processes in patients with OCD.MethodsSixteen OCD patients and 20 healthy controls (HCs) were recruited. We compared in prefrontal alpha and beta band activity derived from magnetoencephalography (MEG) between patients with OCD and HCs during multiple phases of information processing associated with working memory, especially in post-trial period of the visuospatial working memory task (the delayed matching-to‐sample task), which is presumed to be related to the information removal process of working memory.ResultsPrefrontal post-trial beta power change (presumed to occur at high levels during the post-trial period) exhibited significant reductions in patients with OCD compared to HCs. In addition, the post-trial beta power change was negatively correlated with Obsessive-Compulsive Inventory–Revised total scores in patients with OCD.ConclusionsThese findings suggest that impairment in the removal of information from working memory might be a key mechanism underlying the inability of OCD patients to rid themselves of their obsessions.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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