Revista Brasileira de Psiquiatria | |
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates | |
Christine Lochner1  Nathaniel Mcgregor1  Sian Hemmings1  Brian H. Harvey1  Elsie Breet1  Sonja Swanevelder1  Dan J. Stein1  | |
关键词: Obsessive-compulsive disorder; symptom subtype; trauma; genetics; dopamine; | |
DOI : 10.1590/1516-4446-2014-1619 | |
来源: SciELO | |
【 摘 要 】
Objective:In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and polymorphisms in dopaminergic genes has not been investigated in OCD.Methods:Clinical information and polymorphisms in key dopaminergic genes were compared between OCD patients with primary symmetry symptoms and those without.Results:OCD patients with primary symmetry symptoms comprised 46.6% (n=210) of the sample (n=451), and were older (p < 0.01), had longer illness duration (p < 0.01), higher OCD severity scores (p = 0.01), and greater comorbidity (p < 0.01) than those without. In Caucasians (n=343), genotype frequency differed significantly between groups for ANKK1 rs1800497, with more OCD patients with symmetry symptoms being homozygous for the A2 (CC) genotype (χ2 = 7.296; p = 0.026).Conclusion:Symmetry symptoms have some distinct clinical features and may represent a marker of severity in OCD. However, clinical associations, in combination with the association found with the ANKK1 rs1800497 A2 variant, suggest that primary symmetry symptoms may represent a distinctive clinical and psychobiological profile.
【 授权许可】
CC BY-NC
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