Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future

Irish Veterinary Journal

Review

Morgane Mitermite¹  Damien Farrell¹  Ruoyao Ma²  Jose Maria Urtasun Elizari³  Stephen V. Gordon⁴ 

[1] UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland;UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland;Department of Microbiology and Immunology, Weill Cornell Medical College, 10065, New York, NY, USA;UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland;Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, Netherlands;UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland;UCD School of Medicine, University College Dublin, Dublin, Ireland;UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland;UCD Conway Institute, University College Dublin, Dublin, Ireland;

关键词: Mycobacterium bovis;    Tuberculosis;    TB;    Genomics;    Virulence;   

DOI  :  10.1186/s13620-023-00257-6

 received in 2022-11-06, accepted in 2023-09-19,  发布年份 2023

来源: Springer

【 摘 要 】

Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.

【 授权许可】

CC BY   
© The Author(s) 2023