Mesenchymal stem cell-derived extracellular vesicles for treatment of bone loss within periodontitis in pre-clinical animal models: a meta-analysis

BMC Oral Health

Research

Huan Zhou¹  Ang Li¹  Chun-Hui Zhu¹  Yan-Xin Qi²  Dan-Dan Pei² 

[1] Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, China;Department of Periodontology, College of Stomatology, Xi’an Jiaotong University, Xi’an, China;Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, China;Department of Prosthodontics, College of Stomatology, Xi’an Jiaotong University, Xi’an, China;

关键词: Mesenchymal stem cell;    Extracellular vesicle;    Periodontitis;    Bone regeneration;   

DOI  :  10.1186/s12903-023-03398-w

 received in 2023-02-04, accepted in 2023-09-09,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMesenchymal stem cell-derived extracellular vesicles (MSC-EVs) represent an effective and promising strategy for periodontitis, although studies remain pre-clinical. Herein, a meta-analysis was conducted to assess the efficacy of MSC-EVs in animal models of periodontitis.MethodsThe PubMed, Web of Science, and Embase electronic databases were searched up to Dec 2022 to retrieve preclinical studies examining the use of MSC-EVs for periodontitis treatment. Meta-analyses and sub-group analyses were performed to assess the effect of MSC-EVs on Bone Volume/Total Volume (BV/TV) or the distance between the cementoenamel junction and alveolar bone crest (CEJ-ABC) in pre-clinical animal models of periodontitis.Results11 studies published from Mar 2019 to Oct 2022 met the inclusion criteria. Overall, MSC-EVs contributed to periodontal bone regeneration in the inflammatory bone loss area due to periodontitis, as represented by a weighted mean difference (WMD) of 14.07% (95% CI = 6.73, 21.41%, p < 0.001) for BV/TV and a WMD of -0.12 mm (95% CI= -0.14, -0.11 mm, p < 0.001) for CEJ-ABC. However, sub-analysis suggested that there was no significant difference in CEJ-ABC between studies with bioactive scaffolds and studies without bioactive scaffolds (p = 0.60).ConclusionsThe present study suggests that MSC-EVs may represent an attractive therapy for the treatment of inflammatory bone loss within periodontitis.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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