Bioresorbable polymer matrices impregnated with BMP-2

4th School-Seminar of Young Russian Scientists "Problems of Sustainable Regional Development", dedicated to the 70th anniversary of Academician of the Russian Academy of Sciences Arnold Kirillovich Tulokhonov

自然科学（总论）

Minaeva, S.A.^1 ; Antonov, E.N.^1 ; Vasilyev, A.V.^2 ; Bukharova, T.B.^2 ; Galitsina, E.V.^2 ; Popov, V.K.^1

IPT RAS, FSRC Crystallography and Photonics RAS, Troitsk, Moscow

108840, Russia^1

Research Centre for Medical Genetics, Moscow

115522, Russia^2

关键词: Bioresorbable polymers;    Bone morphogenetic protein-2;    Cytocompatibility;    Laser sintering;    Mesenchymal stem cell;    Physiological saline;    Poly lactic-co-glycolic acid;    Surface-selective laser sintering;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/320/1/012053/pdf
DOI  :  10.1088/1755-1315/320/1/012053

学科分类：自然科学（综合）

来源: IOP

【 摘 要 】

Bioresorbable matrices from poly(lactic-co-glycolic acid) containing therapeutically significant concentrations of bone morphogenetic protein 2 (BMP-2) was formed by super-critical fluid encapsulation and surface-selective laser sintering. Biocompatibility of these matrices and the kinetics of BMP-2 release from their volume into physiological saline was investigated. It was shown experimentally that the release of BMP-2 was almost uniform for 15 days. The subsequent use of laser sintering contributed to a longer retention of BMP-2. High cytocompatibility of the obtained matrices with cultures of mesenchymal stem cells was shown in vitro.