Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysis

BMC Endocrine Disorders

Research

Seyedeh Mahdieh Namayandeh¹  Hossein Fallahzadeh¹  Sayedah Sarah Mousavi²  Mehdi Mollahosseini³  Masoud Rahmanian⁴ 

[1]Center for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences and Health Services, Shohaday-E-Gomnam Blvd., Alem Sq., Yazd, Iran

[2]Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences and Health Services, Shohaday-E-Gomnam Blvd., Alem Sq., Yazd, Iran

[3]Department of Community Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences and Health Services, Shohaday-E-Gomnam Blvd., Alem Sq., Yazd, Iran

[4]Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Shohaday-E-Gomnam Blvd., Alem Sq., Yazd, Iran

关键词: Diabetes;    Lifestyle modification;    Metformin;    Primary prevention;    Systematic review;    Meta-analysis;   

DOI  :  10.1186/s12902-023-01445-9

 received in 2022-11-12, accepted in 2023-08-30,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundConcerning ascending trend in the prevalence of chronic type II diabetes, prevention and the development of an effective approach after the recognition of at-risk individuals is crucial. This study aims to investigate comparing the influence of lifestyle modification and metformin interventions in the prevention of type II diabetes developments.MethodThe search was conducted using PubMed, Google Scholar, Scopus and Web of Science databases. The inclusion criteria include randomized controlled trials (RCT) which studied both lifestyle modification and metformin interventions in the population above 18 years old without a history of any type of diabetes. After excluding studies with intervention time of fewer than 6 months, a systematic review and meta-analysis were performed to evaluate relative risk (RR) with a confidence interval (CI) of 95% of type II diabetes development.ResultsData from 5 studies were included in the meta-analysis. The population also consists of individuals with a mean age of 50 years old with BMI and FBS of 35.5 and 104.7 mg/dl respectively. Participants range of prevention years was between 2–3 years with a mean of 2.8 years. Lifestyle modification decreases the probability of the incidence of type II diabetes by 25.3% (RR: 0.747, 95% CI, 0.6—0.92) compared to the metformin intervention (p-value = 0.007). Our results indicate that long-term lifestyle modifications can prevent diabetes type II and decrease diabetes mellitus incidence down to one-quarter in comparison to metformin.ConclusionLifestyle modification can be more efficacious than metformin in diminishing the incidence of type II diabetes. Therefore, lifestyle modification can be a therapeutic strategy for controlling type II diabetes incidence, especially in high-risk individuals.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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