Mediterranean dietary pattern and depression: the PREDIMED randomized trial

BMC Medicine

Lluis Serra-Majem²  Julia Wärnberg^1,10  Alfredo Gea⁸  Emilio Ros⁴  Rosa María Lamuela-Raventós¹  Jose Alfredo Martínez⁶  Xavier Pintó⁷  José Lapetra³  Enrique Gómez-Gracia^1,10  Dora Romaguera^1,14  Fernando Arós^1,11  Maria Isabel Covas^1,12  Dolores Corella⁹  Jordi Salas-Salvadó⁵  Ramón Estruch^1,13  Miguel Angel Martínez-González⁸  Almudena Sánchez-Villegas² 

[1] Nutrition and Food Science Department–XaRTA, INSA, University of Barcelona, Barcelona, Spain;Department of Clinical Sciences, University of Las Palmas de Gran Canaria, PO Box 550, 35080 Las Palmas de Gran Canaria, Spain;Department of Family Medicine, Primary Care Division of Sevilla, Centro de Salud San Pablo, Sevilla, Spain;Institut d’Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clınic, Barcelona, Spain;Human Nutrition Unit, IISPV, Universitat Rovira i Virgili, Reus, Spain;Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain;Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain;Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain;Department of Preventive Medicine, University of Valencia, Valencia, Spain;Department of Preventive Medicine, University of Malaga, Malaga, Spain;Department of Cardiology, University Hospital Txagorritxu, Vitoria, Spain;Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d’Investigacio Medica (IMIM), Barcelona, Spain;Department of Internal Medicine, Institut d’Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain;Research Unit, University Hospital Son Espases, Palma de Mallorca, Spain

关键词: Diabetes;    Low-fat;    Olive oil;    Nuts;    Primary prevention;    Trial;    Depression;    Mediterranean diet;   

Others  :  855689
DOI  :  10.1186/1741-7015-11-208

 received in 2013-04-02, accepted in 2013-08-02,  发布年份 2013

【 摘 要 】

Background

A few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention.

Methods

This was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevención con Dieta Mediterránea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression.

Results

We identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98).

Conclusions

The result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2.

Trial registration

This trial has been registered in the Current Controlled Trials with the number ISRCTN 35739639

【 授权许可】

   
2013 Sanchez-Villegas et al.; licensee BioMed Central Ltd.

【 图 表 】

【 参考文献 】

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