Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study

Molecular Brain

Research

Kim Henningsen¹  Bianka Szöllősi¹  Tomonori Takeuchi²  Nobuhiro Nakanishi³  Richard G.M. Morris⁴  Natsumi Minami⁵  Makoto Tamura⁶  Betina Elfving⁷  Erik Kaadt⁷  Kristoffer Højgaard⁸ 

[1] Danish Research Institute of Translational Neuroscience – DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, DK8000, Aarhus C, Denmark;Danish Research Institute of Translational Neuroscience – DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, DK8000, Aarhus C, Denmark;Center for Proteins in Memory – PROMEMO, Department of Biomedicine, Danish National Research Foundation, Aarhus University, DK8000, Aarhus C, Denmark;Gftd DeSci, Gftd DAO, 162-0044, Tokyo, Japan;Data Science Department, Mitsubishi Tanabe Pharma Corporation, 227-0033, Kanagawa, Japan;Laboratory for Cognitive Neuroscience, Edinburgh Neuroscience, The University of Edinburgh, EH8 9JZ, Edinburgh, UK;Neuroscience Research Unit, Mitsubishi Tanabe Pharma Corporation, 227-0033, Kanagawa, Japan;Neuroscience Research Unit, Mitsubishi Tanabe Pharma Corporation, 227-0033, Kanagawa, Japan;NeuroDiscovery Lab, Mitsubishi Tanabe Pharma Holdings America Inc, 02139, Cambridge, MA, USA;Translational Neuropsychiatry Unit, Department of Clinical medicine, Aarhus University, DK8200, Aarhus N, Denmark;Translational Neuropsychiatry Unit, Department of Clinical medicine, Aarhus University, DK8200, Aarhus N, Denmark;Danish Research Institute of Translational Neuroscience – DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, DK8000, Aarhus C, Denmark;

关键词: AGAP3;    Novelty;    Memory consolidation;    Hippocampus;    Dopamine;    Dopamine receptor antagonist;    Locus coeruleus;    Immediate-early gene;    Behavioural tagging;    Synaptic tagging and capture hypothesis;   

DOI  :  10.1186/s13041-023-01056-4

 received in 2023-06-30, accepted in 2023-09-18,  发布年份 2023

来源: Springer

【 摘 要 】

Novelty-induced memory consolidation is a well-established phenomenon that depends on the activation of a locus coeruleus-hippocampal circuit. It is associated with the expression of activity-dependent genes that may mediate initial or cellular memory consolidation. Several genes have been identified to date, however, to fully understand the mechanisms of memory consolidation, additional candidates must be identified. In this cross-species study, we used a contextual novelty-exploration paradigm to identify changes in gene expression in the dorsal hippocampus of both mice and rats. We found that changes in gene expression following contextual novelty varied between the two species, with 9 genes being upregulated in mice and 3 genes in rats. Comparison across species revealed that ArfGAP with a GTPase domain, an ankyrin repeat and PH domain 3 (Agap3) was the only gene being upregulated in both, suggesting a potentially conserved role for Agap3. AGAP3 is known to regulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor trafficking in the synapse, which suggests that increased transcription of Agap3 may be involved in maintaining functional plasticity. While we identified several genes affected by contextual novelty exploration, we were unable to fully reverse these changes using SCH 23390, a dopamine D1/D5 receptor antagonist. Further research on the role of AGAP3 in novelty-induced memory consolidation could lead to better understanding of this process and guide future research.

【 授权许可】

CC BY   
© Min Zhuo, Bong-Kiun Kaang and BioMed central Ltd. 2023

【 图 表 】

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Fig. 2