Ae index is an independent predictor of kidney stone recurrence in overweight and obese patients

BMC Urology

Research

Kaiguo Xia¹  Qiao Qi¹  Yuexian Xu¹  Rui Yao¹  Qingfeng Huang¹  Zongyao Hao¹  Jiashan Pan¹ 

[1] Department of Urology, The First Affiliated Hospital of Anhui Medical University, 230022, Hefei, China;Institute of Urology, Anhui Medical University, 230022, Hefei, Anhui, China;Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, 230022, Hefei, Anhui, China;

关键词: Apo B;    eGFR;    Ae index;    Kidney stone recurrence;    Overweight;    Obesity;   

DOI  :  10.1186/s12894-023-01321-7

 received in 2023-04-15, accepted in 2023-09-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundFinding some convenient and economical indicators to initially screen overweight and obese patients at high risk of kidney stone recurrence can help them prevent stone recurrence with lower medical cost. The purpose of this article is to determine the clinical value of Ae index (Apo B × 1000/eGFR) as an independent predictor for kidney stone recurrence in overweight and obese populations.MethodsWe queried the electronic medical records of patients with kidney stone operated at our hospital from March 2016 to March 2022, and selected BMI ≥ 25 kg/m2 as the study population and divided the patients into stone recurrence group and non-recurrence group. Relevant parameters of routine blood and biochemical test, glycated serum protein (GSP), and history of hypertension and hyperglycemia were collected. Then the Chi-square test, independent samples t-test or Wilcoxon rank-sum test were used to calculate the differences between the two groups of data. Next, we performed univariate and multivariate logistic regression analysis to screen out the most significant variables Apo B and eGFR, and then we calculated the Ae index using the formula Apo B × 1000/eGFR, and analyzed the relationship between Ae index and kidney stone recurrence.ResultsUnivariate analysis found that Apo B (OR:8.376,95%CI:3.093–22.680), Creatinine (OR:1.012,95%CI:1.003–1.021), Cystatin C(OR:2.747,95%CI:1.369–5.508), LDL-C (OR:1.588,95%CI:1.182–2.134), TC (OR:1.543,95%CI:1.198–1.988) were positively associated, eGFR (OR:0.980,95%CI:0.970–0.991) was negatively associated with kidney stone recurrence. And multivariate logistic regression analysis suggested that Apo B (OR:11.028, 95%CI:3.917–31.047) and eGFR (OR:0.976, 95%CI:0.965–0.988) were the most significant factors. Then we calculated Ae index and analyzed it, the sensitivity was 74.26% and the specificity was 60.00%, higher than either individual variable. Its smoothed curve revealed a non-linear relationship between them with the inflection point of 9.16. And the OR on the left side of the inflection point was 1.574 (95% CI: 1.228–2.018), whereas the OR on the right side of the inflection point was 1.088 (95% CI: 1.007–1.177).ConclusionsAe index is an easily calculated and obtained index that has some predictive value for kidney stone recurrence in overweight and obese patients, which is of interest.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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