Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Journal of Nanobiotechnology

Review

Defeng Li¹  Xiaohua Pan²  Yujie Liang³  Qisong Liu⁴ 

[1] Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, 518020, Shenzhen, China;Department of Orthopaedics, The Second Affiliated Hospital of Shenzhen University (People’s Hospital of Shenzhen Baoan District), China, 518000, Shenzhen, China;Department of Orthopaedics, The Second Affiliated Hospital of Shenzhen University (People’s Hospital of Shenzhen Baoan District), China, 518000, Shenzhen, China;Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Institute of Mental Health, Shenzhen Mental Health Center, Shenzhen Clinical Research Center for Mental Disorders, 518020, Shenzhen, Guangdong, China;National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, Southern University of Science and Technology, Shenzhen, China;Department of Orthopaedics, The Second Affiliated Hospital of Shenzhen University (People’s Hospital of Shenzhen Baoan District), China, 518000, Shenzhen, China;

关键词: Exosome;    Extracellular vesicles;    Surface modification;    Targeted delivery;   

DOI  :  10.1186/s12951-023-02081-0

 received in 2023-07-04, accepted in 2023-08-26,  发布年份 2023

来源: Springer

【 摘 要 】

Extracellular vesicles (EVs) are 30–150 nm membrane-bound vesicles naturally secreted by cells and play important roles in intercellular communication by delivering regulatory molecules such as proteins, lipids, nucleic acids and metabolites to recipient cells. As natural nano-carriers, EVs possess desirable properties such as high biocompatibility, biological barrier permeability, low toxicity, and low immunogenicity, making them potential therapeutic delivery vehicles. EVs derived from specific cells have inherent targeting capacity towards specific cell types, which is yet not satisfactory enough for targeted therapy development and needs to be improved. Surface modifications endow EVs with targeting abilities, significantly improving their therapeutic efficiency. Herein, we first briefly introduce the biogenesis, composition, uptake and function of EVs, and review the cargo loading approaches for EVs. Then, we summarize the recent advances in surface engineering strategies of EVs, focusing on the applications of engineered EVs for targeted therapy. Altogether, EVs hold great promise for targeted delivery of various cargos, and targeted modifications show promising effects on multiple diseases.Graphical Abstract

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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