Diagnostic and therapeutic value of P2Y12R in epilepsy

Frontiers in Pharmacology

Pharmacology

Jun Liu¹  Xiang Chen²  Bin-Lu Deng²  Jie Liu³  Qi Wang⁴  Ting-Ting Liu⁵  Li Zhang⁶  Jie Yang⁷ 

[1] Department of Geriatric Neurology, Qinglongchang Ward, Chengdu Sixth People’s Hospital, Chengdu, China;Department of Neurology, School of Clinical Medicine, Southwest Medical University, Luzhou, China;Department of Neurology, School of Clinical Medicine, Southwest Medical University, Luzhou, China;Department of Neurology, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Chengdu, China;Department of Neurology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China;Department of Neurology, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Chengdu, China;Department of Neurology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China;Electrophysiology Unit, Department of Neurology, Chengdu Fourth People’s Hospital, Chengdu, China;Zunyi Medical University, Zunyi, China;

关键词: P2Y12 receptor;    epilepsy;    seizures;    neuroinflammation;    diagnosis;    therapy;   

DOI  :  10.3389/fphar.2023.1179028

 received in 2023-03-03, accepted in 2023-04-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

There lacks biomarkers in current epilepsy diagnosis, and epilepsy is thus exposed to inadequate treatment, making it necessarily important to conduct search on new biomarkers and drug targets. The P2Y12 receptor is primarily expressed on microglia in the central nervous system, and acts as intrinsic immune cells in the central nervous system mediating neuroinflammation. In previous studies, P2Y12R in epilepsy has been found capable of controlling neuroinflammation and regulating neurogenesis as well as immature neuronal projections, and its expression is altered. P2Y12R is involved in microglia inhibition of neuronal activity and timely termination of seizures in acute seizures. In status epilepticus, the failure of P2Y12R in the process of “brake buffering” may not terminate the neuronal hyperexcitability timely. In chronic epilepsy, neuroinflammation causes seizures, which can in turn induce neuroinflammation, while on the other hand, neuroinflammation leads to neurogenesis, thereby causing abnormal neuronal discharges that give rise to seizures. In this case, targeting P2Y12R may be a novel strategy for the treatment of epilepsy. The detection of P2Y12R and its expression changes can contribute to the diagnosis of epilepsy. Meanwhile, the P2Y12R single-nucleotide polymorphism is associated with epilepsy susceptibility and endowed with the potential to individualize epilepsy diagnosis. To this end, functions of P2Y12R in the central nervous system were hereby reviewed, the effects of P2Y12R in epilepsy were explored, and the potential of P2Y12R in the diagnosis and treatment of epilepsy was further demonstrated.

【 授权许可】

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Copyright © 2023 Chen, Wang, Yang, Zhang, Liu, Liu, Deng and Liu.