Impact of Stress on Epilepsy: Focus on Neuroinflammation—A Mini Review

International Journal of Molecular Sciences

Claudia Espinosa-Garcia¹  Asheebo Rojas¹  Helena Zeleke² 

[1] Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA 30322, USA;Neuroscience and Behavioral Biology Program, Emory University College of Arts and Sciences, Atlanta, GA 30322, USA;

关键词: epilepsy;    stress;    seizures;    psychiatric comorbidities in epilepsy;    depression;    neuroinflammation;   

DOI  :  10.3390/ijms22084061

来源: DOAJ

【 摘 要 】

Epilepsy, one of the most common neurological disorders worldwide, is characterized by recurrent seizures and subsequent brain damage. Despite strong evidence supporting a deleterious impact on seizure occurrence and outcome severity, stress is an overlooked component in people with epilepsy. With regard to stressor duration and timing, acute stress can be protective in epileptogenesis, while chronic stress often promotes seizure occurrence in epilepsy patients. Preclinical research suggests that chronic stress promotes neuroinflammation and leads to a depressive state. Depression is the most common psychiatric comorbidity in people with epilepsy, resulting in a poor quality of life. Here, we summarize studies investigating acute and chronic stress as a seizure trigger and an important factor that worsens epilepsy outcomes and psychiatric comorbidities. Mechanistic insight into the impact of stress on epilepsy may create a window of opportunity for future interventions targeting neuroinflammation-related disorders.

【 授权许可】

Unknown