Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link

International Journal of Molecular Sciences

Herlinda Bonilla-Jaime¹  Claudia Espinosa-Garcia²  Asheebo Rojas²  Helena Zeleke³ 

[1] Departamento de Biología de la Reproducción, Área de Biología Conductual y Reproductiva, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de Mexico CP 09340, Mexico;Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA 30322, USA;Neuroscience and Behavioral Biology Program, College of Arts and Sciences, Emory University, Atlanta, GA 30322, USA;

关键词: sleep;    seizures;    epilepsy;    neuroinflammation;    neurodegeneration;   

DOI  :  10.3390/ijms222212531

来源: DOAJ

【 摘 要 】

Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic drugs with sleep-modifying side effects. Epilepsy patients with poor sleep quality have intensified seizure frequency and disease progression compared to their well-rested counterparts. A better understanding of the complex relationship between sleep and epilepsy is needed, since approximately 20% of seizures and more than 90% of sudden unexpected deaths in epilepsy occur during sleep. Emerging studies suggest that neuroinflammation, (e.g., the CNS immune response characterized by the change in expression of inflammatory mediators and glial activation) may be a potential link between sleep deprivation and seizures. Here, we review the mechanisms by which sleep deprivation induces neuroinflammation and propose that neuroinflammation synergizes with seizure activity to worsen neurodegeneration in the epileptic brain. Additionally, we highlight the relevance of sleep interventions, often overlooked by physicians, to manage seizures, prevent epilepsy-related mortality, and improve quality of life.

【 授权许可】

Unknown