A mechanistic review of pharmacological activities of homeopathic medicine licorice against neural diseases

Frontiers in Neuroscience

Neuroscience

Aziz Eftekhari¹  Rovshan Khalilov²  Tayebeh Zivari-Ghader³  Sevinj Maharramova⁴  Gvozden Rosić⁵  Dragica Selakovic⁵  Vugar Ali Turksoy⁶  Parvin Zulfugarova⁷  Elham Ahmadian⁸ 

[1] Department of Biochemistry, Faculty of Science, Ege University, İzmir, Turkey;Institute of Molecular Biology and Biotechnologies, Ministry of Science and Education Republic of Azerbaijan, Baku, Azerbaijan;Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan;Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Pharmaceutical Technology and Management, Azerbaijan Medical University, Baku, Azerbaijan;Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia;Department of Public Health, Faculty of Medicine, Bozok University, Yozgat, Turkey;Department of Zoology and Physiology, Faculty of Biology, Baku State University, Baku, Azerbaijan;Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: licorice;    Parkinson;    Alzheimer’s disease;    herbal medicine;    brain;   

DOI  :  10.3389/fnins.2023.1148258

 received in 2023-01-19, accepted in 2023-02-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

The use of medicinal plants has grown in popularity in recent decades because, as natural ingredients, they have fewer adverse effects and are more effective than synthetic alternatives. As a small perennial herb, Glycyrrhiza glabra L. (Licorice) has been investigated for its therapeutic efficacy against neural disorders mainly ischemic stroke as well as the neurodegenerative diseases such as dementia and Alzheimer’s disease, and Parkinson’s disease which has been attributed to its HMGB inhibitory function, reactive oxygen scavenging and anti-inflammatory activity. The objective of current review is to review the evidence for the pharmacological effects of licorice and its vital active components on neurological disorders and the underlying signaling networks. We reviewed Papers published from 2000.1.1 up to 2 January 2023 in web of science, Google Scholar and PubMed data bases using key words including “Licorice,” “Glycyrrhiza glabra L.,” “Glycyrrhizic acid,” “brain,” “neurodegenerative disease,” “Alzheimer’s,” and “Parkinson” were used to search in title/abstracts. Licorice extract and/or its active components can be used safely in therapeutic doses for optimizing the management of a multiple neurodegenerative disorders, and hampering the extent of neural tissue injury and neurologic deficits subsequent to cerebrovascular accidents.

【 授权许可】

Unknown   
Copyright © 2023 Zulfugarova, Zivari-Ghader, Maharramova, Ahmadian, Eftekhari, Khalilov, Turksoy, Rosić and Selakovic.