Literature review on the interdisciplinary biomarkers of multi-target and multi-time herbal medicine therapy to modulate peripheral systems in cognitive impairment

Frontiers in Neuroscience

Neuroscience

Sang-Min Park¹  Soyeon Jeong¹  Soyeong Son¹  Jeongtae Kim²  Kyungsook Jung³  Seung Hyun Lee⁴  Jung-Hee Jang⁵  Yujin Choi⁵  HuiYan Zhao⁶  Jae young Jang⁷ 

[1] College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea;Department of Anatomy, Kosin University College of Medicine, Busan, Republic of Korea;Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Republic of Korea;Interdisciplinary Program in Precision Public Health, Korea University, Seoul, Republic of Korea;KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea;KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea;Korea Convergence Medical Science, Korea Institute of Oriental Medicine, University of Science and Technology, Daejeon, Republic of Korea;School of Electrical, Electronics and Communication Engineering, Korea University of Technology and Education (KOREATECH), Cheonan-si, Republic of Korea;

关键词: Alzheimer’s disease;    interdisciplinary biomarker;    peripheral system;    syndrome differentiation;    traditional medicine;    herbal medicine;   

DOI  :  10.3389/fnins.2023.1108371

 received in 2022-11-26, accepted in 2023-01-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disease characterized by the deposition of amyloid-beta (Aβ) peptide and neurofibrillary tangles in the brain. The approved drug for AD has certain limitations such as a short period of cognitive improvement effect; moreover, the development of drug for AD therapeutic single target for Aβ clearance in brain ended in failure. Therefore, diagnosis and treatment of AD using a multi-target strategy according to the modulation of the peripheral system, which is not only limited to the brain, is needed. Traditional herbal medicines can be beneficial for AD based on a holistic theory and personalized treatment according to the time-order progression of AD. This literature review aimed to investigate the effectiveness of herbal medicine therapy based on syndrome differentiation, a unique theory of traditional diagnosis based on the holistic system, for multi-target and multi-time treatment of mild cognitive impairment or AD stage. Possible interdisciplinary biomarkers including transcriptomic and neuroimaging studies by herbal medicine therapy for AD were investigated. In addition, the mechanism by which herbal medicines affect the central nervous system in connection with the peripheral system in an animal model of cognitive impairment was reviewed. Herbal medicine may be a promising therapy for the prevention and treatment of AD through a multi-target and multi-time strategy. This review would contribute to the development of interdisciplinary biomarkers and understanding of the mechanisms of action of herbal medicine in AD.

【 授权许可】

Unknown   
Copyright © 2023 Park, Lee, Zhao, Kim, Jang, Choi, Jeong, Son, Jung and Jang.