Impact of thyroid autoimmunity and vitamin D on in vitro fertilization/intracytoplasmic sperm injection outcomes among women with normal thyroid function

Frontiers in Endocrinology

Endocrinology

Ning Huang¹  Lin Zeng¹  Rong Li¹  Hongbin Chi¹  Yalong Liu¹  Zining He¹  Yang Wang¹ 

[1] Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China;Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China;Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing, China;

关键词: in vitro;    intracytoplasmic sperm injection;    thyroid autoimmunity;    vitamin D;    early pregnancy outcomes;   

DOI  :  10.3389/fendo.2023.1098975

 received in 2022-11-15, accepted in 2023-04-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

This prospective cohort study aimed to determine the impact of thyroid autoimmunity and total 25-hydroxyvitamin D concentration on early pregnancy outcomes in women undergoing in vitro fertilization/intracytoplasmic sperm injection who had intact thyroid function. The study included 1,297 women who underwent in vitro fertilization/intracytoplasmic sperm injection cycles, although only 588 patients received fresh embryo transfer. The study endpoints were clinical pregnancy, ongoing pregnancy, ectopic pregnancy, and early miscarriage rates. Our study found that the total 25-hydroxyvitamin D serum concentrations (P<0.001) and anti-Mullerian hormone levels (P=0.019) were lower among patients in the TAI group (n=518) than among those in the non-TAI group (n=779). Additionally, the study population in each group was divided into three subgroups according to the total vitamin D status based on clinical practice guidelines (deficient, <20 ng/mL; insufficient, 21–29 ng/mL; and sufficient, ≥30 ng/mL), TAI group: sufficient, n=144; insufficient, n=187; and deficient, n=187; non-TAI group: sufficient, n=329; insufficient, n=318, and deficient, n=133. In the TAI group, the number of good-quality embryos decreased in patients with vitamin D deficiency (P=0.007). Logistic regression analysis indicated that aging prevented women from achieving clinical (P=0.024) and ongoing pregnancy (P=0.026). The current findings suggest that patients with TAI had reduced serum vitamin D concentration. Furthermore, in the TAI group, the number of good-quality embryos decreased in patients with vitamin D deficiency. Finally, aging adversely impacted achieving clinical and ongoing pregnancy.

【 授权许可】

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Copyright © 2023 Liu, He, Huang, Zeng, Wang, Li and Chi