Immunomodulatory Effects of Vitamin D in Thyroid Diseases

Nutrients

Marina Caputo¹  Flavia Prodam¹  Gianluca Aimaretti²  Chiara Mele²  Paolo Marzullo²  Loredana Pagano³  Alessandro Bisceglia³  MariaTeresa Samà⁴  Marco Zavattaro⁴ 

[1] Department of Health Sciences, University of Piemonte Orientale UPO, 28100 Novara, Italy;Department of Translational Medicine, University of Piemonte Orientale UPO, 28100 Novara, Italy;Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy;Division of Endocrinology, University Hospital “Maggiore della Carità”, 28100 Novara, Italy;

关键词: vitamin D;    immune system;    thyroid autoimmunity;    thyroid cancer;   

DOI  :  10.3390/nu12051444

来源: DOAJ

【 摘 要 】

Vitamin D is a secosteroid with a pleiotropic role in multiple physiological processes. Besides the well-known activity on bone homeostasis, recent studies suggested a peculiar role of vitamin D in different non-skeletal pathways, including a key role in the modulation of immune responses. Recent evidences demonstrated that vitamin D acts on innate and adaptative immunity and seems to exert an immunomodulating action on autoimmune diseases and cancers. Several studies demonstrated a relationship between vitamin D deficiency, autoimmune thyroid disorders, and thyroid cancer. This review aims to summarize the evidences on the immunomodulatory effect of vitamin D on thyroid diseases.

【 授权许可】

Unknown