Alterations of gut microbiota are associated with brain structural changes in the spectrum of Alzheimer's disease: the SILCODE study in Hainan cohort

Frontiers in Aging Neuroscience

Aging Neuroscience

Can Sheng¹  Xianfeng Yu²  Feng Chen³  Beiqi He⁴  Liang Zhang⁴  Ying Han⁵ 

[1] Department of Neurology, The Affiliated Hospital of Jining Medical University, Jining, China;Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China;Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China;School of Biomedical Engineering, Hainan University, Haikou, China;School of Biomedical Engineering, Hainan University, Haikou, China;Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China;Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China;National Clinical Research Center for Geriatric Disorders, Beijing, China;

关键词: Alzheimer's disease;    gut microbiota;    16S ribosomal RNA;    brain structural;    magnetic resonance imaging;   

DOI  :  10.3389/fnagi.2023.1216509

 received in 2023-05-04, accepted in 2023-06-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe correlation between gut microbiota and Alzheimer's disease (AD) is increasingly being recognized by clinicians. However, knowledge about the gut–brain–cognition interaction remains largely unknown.MethodsOne hundred and twenty-seven participants, including 35 normal controls (NCs), 62 with subjective cognitive decline (SCD), and 30 with cognitive impairment (CI), were included in this study. The participants underwent neuropsychological assessments and fecal microbiota analysis through 16S ribosomal RNA (rRNA) Illumina Miseq sequencing technique. Structural MRI data were analyzed for cortical anatomical features, including thickness, sulcus depth, fractal dimension, and Toro's gyrification index using the SBM method. The association of altered gut microbiota among the three groups with structural MRI metrics and cognitive function was evaluated. Furthermore, co-expression network analysis was conducted to investigate the gut–brain–cognition interactions.ResultsThe abundance of Lachnospiraceae, Lachnospiracea_incertae_sedis, Fusicatenibacter, and Anaerobutyricum decreased with cognitive ability. Rikenellaceae, Odoribacteraceae, and Alistipes were specifically enriched in the CI group. Mediterraneibacter abundance was correlated with changes in brain gray matter and cerebrospinal fluid volume (p = 0.0214, p = 0.0162) and significantly with changes in cortical structures in brain regions, such as the internal olfactory area and the parahippocampal gyrus. The three colonies enriched in the CI group were positively correlated with cognitive function and significantly associated with changes in cortical structure related to cognitive function, such as the precuneus and syrinx gyrus.ConclusionThis study provided evidence that there was an inner relationship among the altered gut microbiota, brain atrophy, and cognitive decline. Targeting the gut microbiota may be a novel therapeutic strategy for early AD.

【 授权许可】

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Copyright © 2023 He, Sheng, Yu, Zhang, Chen and Han.