Altered gut microbiota in older adults with mild cognitive impairment: a case-control study

Frontiers in Aging Neuroscience

Aging Neuroscience

Yi-Ping Chao¹  Yen-Ling Chiu²  Yi-Chien Liu³  Yen-Jun Lai⁴  Chen-Ching Lin⁵  Kang-Chen Fan⁶  Yi-Fang Chuang⁷ 

[1] Department of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan;Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan;Department of Medical Research, Far Eastern Memorial Hospital, Taipei, Taiwan;Graduate Program in Biomedical Informatics and Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan;Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan;Department of Neurology, Cardinal Tien Hospital, New Taipei, Taiwan;Division of Medical Imaging, Department of Radiology, Far Eastern Memorial Hospital, New Taipei, Taiwan;Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan;School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;Institute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan;Department of Psychiatry, Far Eastern Memorial Hospital, New Taipei, Taiwan;

关键词: mild cognitive impairment;    gut microbiota;    16S ribosomal RNA;    cognitive functions;    structural brain imaging;   

DOI  :  10.3389/fnagi.2023.1162057

 received in 2023-02-09, accepted in 2023-05-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe microbiota-gut-brain axis is implicated in Alzheimer’s disease. Gut microbiota alterations in mild cognitive impairment (MCI) are inconsistent and remain to be understood. This study aims to investigate the gut microbial composition associated with MCI, cognitive functions, and structural brain differences.MethodsA nested case-control study was conducted in a community-based prospective cohort where detailed cognitive functions and structural brain images were collected. Thirty-one individuals with MCI were matched to sixty-five cognitively normal controls by age strata, gender, and urban/rural area. Fecal samples were examined using 16S ribosomal RNA (rRNA) V3–V4 sequencing. Compositional differences between the two groups were identified and correlated with the cognitive functions and volumes/thickness of brain structures.ResultsThere was no significant difference in alpha and beta diversity between MCIs and cognitively normal older adults. However, the abundance of the genus Ruminococcus, Butyricimonas, and Oxalobacter decreased in MCI patients, while an increased abundance of nine other genera, such as Flavonifractor, were found in MCIs. Altered genera discriminated MCI patients well from controls (AUC = 84.0%) and were associated with attention and executive function.ConclusionThis study provides insights into the role of gut microbiota in the neurodegenerative process.

【 授权许可】

Unknown   
Copyright © 2023 Fan, Lin, Liu, Chao, Lai, Chiu and Chuang.