Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer

Frontiers in Immunology

Immunology

Laura Esparcia-Pinedo¹  Arantzazu Alfranca²  Nuria Romero-Laorden³ 

[1] Immunology Department, Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Madrid, Spain;Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain;Immunology Department, Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Madrid, Spain;Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain;Cátedra Universidad Autónoma de Madrid (UAM)-Fundación Instituto Roche de Medicina Personalizada de Precisión, Madrid, Spain;Centro de Investigación Biomédica en Red Cardiovascular, CIBERCV, Madrid, Spain;Medical Oncology Department, Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Madrid, Spain;Cátedra Universidad Autónoma de Madrid (UAM)-Fundación Instituto Roche de Medicina Personalizada de Precisión, Madrid, Spain;

关键词: tertiary lymphoid structures;    B cells;    adaptive anti-tumor response;    TLS modulation;    immunotherapy;   

DOI  :  10.3389/fimmu.2023.1231315

 received in 2023-05-30, accepted in 2023-07-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tertiary lymphoid structures (TLSs) are clusters of lymphoid cells with an organization that resembles that of secondary lymphoid organs. Both structures share common developmental characteristics, although TLSs usually appear in chronically inflamed non-lymphoid tissues, such as tumors. TLSs contain diverse types of immune cells, with varying degrees of spatial organization that represent different stages of maturation. These structures support both humoral and cellular immune responses, thus the correlation between the existence of TLS and clinical outcomes in cancer patients has been extensively studied. The finding that TLSs are associated with better prognosis in some types of cancer has led to the design of therapeutic strategies based on promoting the formation of these structures. Agents such as chemokines, cytokines, antibodies and cancer vaccines have been used in combination with traditional antitumor treatments to enhance TLS generation, with good results. The induction of TLS formation therefore represents a novel and promising avenue for the treatment of a number of tumor types.

【 授权许可】

Unknown   
Copyright © 2023 Esparcia-Pinedo, Romero-Laorden and Alfranca