The buzz in the field: the interaction between viruses, mosquitoes, and metabolism

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Oshani C. Ratnayake¹  Rushika Perera¹  Karla Saavedra-Rodriguez¹  Nunya Chotiwan² 

[1] Center for Vector-borne Infectious Diseases, Dept. of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States;Center for Vector-borne Infectious Diseases, Dept. of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States;Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand;

关键词: Aedes aegypti;    mosquito;    Wolbachia;    metabolism;    lipids;    dengue;    Zika;    virus;   

DOI  :  10.3389/fcimb.2023.1128577

 received in 2022-12-20, accepted in 2023-03-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Among many medically important pathogens, arboviruses like dengue, Zika and chikungunya cause severe health and economic burdens especially in developing countries. These viruses are primarily vectored by mosquitoes. Having surmounted geographical barriers and threat of control strategies, these vectors continue to conquer many areas of the globe exposing more than half of the world’s population to these viruses. Unfortunately, no medical interventions have been capable so far to produce successful vaccines or antivirals against many of these viruses. Thus, vector control remains the fundamental strategy to prevent disease transmission. The long-established understanding regarding the replication of these viruses is that they reshape both human and mosquito host cellular membranes upon infection for their replicative benefit. This leads to or is a result of significant alterations in lipid metabolism. Metabolism involves complex chemical reactions in the body that are essential for general physiological functions and survival of an organism. Finely tuned metabolic homeostases are maintained in healthy organisms. However, a simple stimulus like a viral infection can alter this homeostatic landscape driving considerable phenotypic change. Better comprehension of these mechanisms can serve as innovative control strategies against these vectors and viruses. Here, we review the metabolic basis of fundamental mosquito biology and virus-vector interactions. The cited work provides compelling evidence that targeting metabolism can be a paradigm shift and provide potent tools for vector control as well as tools to answer many unresolved questions and gaps in the field of arbovirology.

【 授权许可】

Unknown   
Copyright © 2023 Ratnayake, Chotiwan, Saavedra-Rodriguez and Perera

【 图 表 】

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