Symbiotic Wolbachia in mosquitoes and its role in reducing the transmission of mosquito-borne diseases: updates and prospects

Frontiers in Microbiology

Microbiology

Andrea Sciarretta¹  Awoke Minwuyelet²  Getnet Atenafu²  Irene Magnifico³  Giulio Petronio Petronio³  Roberto Di Marco³  Daria Nicolosi⁴  Delenasaw Yewhalaw⁵ 

[1] Department of Agriculture, Environment and Food Sciences, Università degli Studi del Molise, Campobasso, Italy;Department of Biology, College of Natural and Computational Sciences, Debre Markos University, Debre Markos, Ethiopia;Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy;Department of Pharmaceutical and Health Sciences, Università degli Studi di Catania, Catania, Italy;Tropical and Infectious Diseases Research Center, Jimma University, Jimma, Ethiopia;Faculty of Health Sciences, School of Medical Laboratory Sciences, Jimma University, Jimma, Ethiopia;

关键词: mosquito symbiont;    Wolbachia;    Aedes;    Anopheles;    Culex;    mosquito;    mosquito-borne diseases;   

DOI  :  10.3389/fmicb.2023.1267832

 received in 2023-07-27, accepted in 2023-09-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

Mosquito-borne diseases such as malaria, dengue fever, West Nile virus, chikungunya, Zika fever, and filariasis have the greatest health and economic impact. These mosquito-borne diseases are a major cause of morbidity and mortality in tropical and sub-tropical areas. Due to the lack of effective vector containment strategies, the prevalence and severity of these diseases are increasing in endemic regions. Nowadays, mosquito infection by the endosymbiotic Wolbachia represents a promising new bio-control strategy. Wild-infected mosquitoes had been developing cytoplasmic incompatibility (CI), phenotypic alterations, and nutrition competition with pathogens. These reduce adult vector lifespan, interfere with reproduction, inhibit other pathogen growth in the vector, and increase insecticide susceptibility of the vector. Wild, uninfected mosquitoes can also establish stable infections through trans-infection and have the advantage of adaptability through pathogen defense, thereby selectively infecting uninfected mosquitoes and spreading to the entire population. This review aimed to evaluate the role of the Wolbachia symbiont with the mosquitoes (Aedes, Anopheles, and Culex) in reducing mosquito-borne diseases. Global databases such as PubMed, Web of Sciences, Scopus, and pro-Quest were accessed to search for potentially relevant articles. We used keywords: Wolbachia, Anopheles, Aedes, Culex, and mosquito were used alone or in combination during the literature search. Data were extracted from 56 articles’ texts, figures, and tables of the included article.

【 授权许可】

Unknown   
Copyright © 2023 Minwuyelet, Petronio, Yewhalaw, Sciarretta, Magnifico, Nicolosi, Di Marco and Atenafu.