Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study

Frontiers in Medicine

Medicine

Doudou Li¹  Zengli Yu²  Yong Li³  Xue Li⁴  Yuming Wang⁴  Han Zhang⁵  Lidan Hu⁶  Shuai Yuan⁷  Susanna C. Larsson⁸ 

[1] College of Public Health, Zhengzhou University, Zhengzhou, China;College of Public Health, Zhengzhou University, Zhengzhou, China;NHC Key Laboratory of Birth Defects Prevention and Henan Key Laboratory of Population Defects Prevention, Zhengzhou, China;Department of Biometry, Institute of Genetic Epidemiology, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany;Henan Provincial People’s Hospital, Zhengzhou University, Zhengzhou, China;Henan Provincial People’s Hospital, Zhengzhou University, Zhengzhou, China;College of Public Health, Zhengzhou University, Zhengzhou, China;The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China;Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Solna, Stockholm, Sweden;Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Solna, Stockholm, Sweden;Unit of Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;

关键词: atopic dermatitis;    chronic kidney disease;    Mendelian randomization;    MR-PRESSO;    bidirectional Mendelian randomization;   

DOI  :  10.3389/fmed.2023.1180596

 received in 2023-03-08, accepted in 2023-06-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundA bidirectional association between atopic dermatitis and chronic kidney disease (CKD) has been revealed in observational studies, whereas the causality of this association was unclear. We conducted a Mendelian randomization study to determine the bidirectional causal association between atopic dermatitis and CKD.MethodsIndependent genetic instruments associated with atopic dermatitis and CKD at the genome-wide significance level were chosen from corresponding meta-analyses of genome-wide association studies. Summary-level data for atopic dermatitis were obtained from the EAGLE Eczema consortium (30,047 cases and 40,835 controls) and FinnGen consortium (7,024 cases and 198,740 controls). Summary-level data for CKD were derived from CKDGen consortium (64,164 cases and 625,219 controls) and FinnGen consortium (3,902 cases and 212,841 controls). The inverse-variance weighted method was used in the main analysis and supplemented with three sensitivity analyses.ResultsGenetic predisposition to atopic dermatitis was associated with an increased risk of CKD. For a one-unit increase in the prevalence of atopic dermatitis, the odds ratio of CKD was 1.07 (95% confidence interval: 1.01–1.12). In the reverse Mendelian randomization analysis, the odds ratio of atopic dermatitis was 1.14 (95% confidence interval: 1.03–1.26) for a one-unit increase in the prevalence of CKD. The associations persisted in sensitivity analyses and no pleiotropy was detected.ConclusionThis Mendelian randomization study suggests a bidirectional positive association between atopic dermatitis and CKD.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Yuan, Li, Li, Yu, Hu, Li, Wang and Larsson.