Assessment of common risk factors of diabetes and chronic kidney disease: a Mendelian randomization study

Frontiers in Endocrinology

Endocrinology

Shuwu Zhao¹  Chen Su¹  Yiming Li² 

[1] Department of Pain, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, China;School of Basic Medicine Science, Naval Medical University/Second Military University, Shanghai, China;

关键词: type 1 diabetes;    type 2 diabetes;    chronic kidney disease;    risk factors;    Mendelian randomization;   

DOI  :  10.3389/fendo.2023.1265719

 received in 2023-07-23, accepted in 2023-08-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe increasing prevalence of diabetes and its significant impact on mortality and morbidity rates worldwide has led to a growing interest in understanding its common risk factors, particularly in relation to chronic kidney disease (CKD). This research article aims to investigate the shared risk factors between type 1 diabetes (T1D), type 2 diabetes (T2D), and CKD using a Mendelian randomization (MR) design.MethodsThe study utilized genome-wide association study (GWAS) datasets for T1D, T2D, and CKD from the FinnGen research project. GWAS summary statistics datasets for 118 exposure traits were obtained from the IEU OpenGWAS database. MR analyses were conducted to examine the causal relationships between exposure traits and each of the three outcomes. Multiple methods, including inverse-variance weighted, weighted median, and MR-Egger, were employed for the MR studies.ResultsPhenome-wide MR analyses revealed that eosinophil percentage exhibited a significant and suggestive causal association with T1D and CKD, respectively, suggesting its potential as a shared risk factor for T1D and CKD. For T2D, 34 traits demonstrated significant associations. Among these 34 traits, 14 were also significantly associated with CKD, indicating the presence of common risk factors between T2D and CKD, primarily related to obesity, height, blood lipids and sex hormone binding globulin, blood pressure, and walking pace.ConclusionThis research has uncovered the eosinophil percentage as a potential common risk factor for both T1D and CKD, while also identifying several traits, such as obesity and blood lipids, as shared risk factors for T2D and CKD. This study contributes to the understanding of the common risk factors between diabetes and CKD, emphasizing the need for targeted interventions to reduce the risk of these diseases.

【 授权许可】

Unknown   
Copyright © 2023 Zhao, Li and Su